S. 5469 — HEART Foundation Act

This section establishes the Heart Security Foundation as a federally chartered nonprofit corporation, not a federal agency, to raise private capital for cardiovascular research, award grants to U.S. research institutions, and prioritize high-impact biomarker research on early-onset events. The Foundation is governed by a five-member board appointed by the NIH Director for four-year terms, may accept private donations and apply for federal grants, must submit annual reports to Congress, and is barred from political advocacy, community organizing, or operating as a health care provider.